Q&A: Loss of Smell & Taste? When Smell & Taste Loss Could Mean Something Serious

During the height of the COVID pandemic, the oddest symptom began to hit headlines. People in the flush of infection and for months after lost their sense of smell. Others stopped wanting to eat, as their sense of taste disappeared. Compared to the other impacts of COVID, like brain fog, lung damage, and death, loss of smell and taste didn't seem so bad.  

But it turns out that losing your sense of smell and taste can lead to serious problems. Changes in these senses can also point to underlying disease.  

We spoke with Jose Mattos, MD, and Steven Munger, PhD, leading experts in smell and taste disorders, to understand more.   

Do a lot of people have smell and taste disorders?

Munger: Yes. These are very common disorders. Probably about 20% of adults are affected by a smell or taste disorder. Many people first notice smell loss. Smell disorders are much more common than taste disorders, although both are certainly impactful for patients. 

How much do we know about what causes smell and taste disorders?

Munger: There are many different types of causes. One that got a lot of attention over the last few years was viruses that affect the oral and nasal cavities. With viruses like COVID-19, a lot of people lost their sense of smell. The flu and the common cold can do that as well. 

But there are many other causes:  

• Head trauma 
• Chemo
• Head and neck focused radiation  
• Medications
• Parkinson's disease  
• Alzheimer's disease 
• Inflammatory disease of the nose 
• Surgical issues, especially in dental surgeries for taste 
• Allergies  

What are some of the most common symptoms that may signal you have a smell or taste disorder, other than the obvious — either you smell nothing or you can't taste things?

Munger: Your senses of smell and taste work together to give you a perception of flavor. Sweet and sour and bitter, these types of things are taste primarily. You can't tell the difference between a lemon and a lime without the different odors that go along with them.  

So a lot of people will first come to their doctor noting that food just doesn't taste right. And that's often what sends you down the road of investigating if this is a smell or taste disorder. 

What are some of the potential health effects of having one of these disorders?

Mattos: The primary impacts are around quality of life and enjoyment of daily activities. Eating and drinking are very social events. If food doesn't taste right, and people don't want to engage in those activities, it can be socially isolating. Folks who have smell and taste disorders can develop depression or anxiety.  

And then there's physical health consequences people can develop, particularly the elderly. If they really diminish their intake of food, they lose nutrition.  

There are also safety consequences. Our sense of smell is for more than just detecting pleasant things. We also use it for detecting hazards in our environment, like: 

• Spoiled or rotten food 
• Smoke or burning
• Gas and propane leaks 

And there are issues with detecting one's own personal hygiene.  

Can smell and taste disorders can sometimes point to underlying health issues? 

Munger: Yes. They can signal a developing neurodegenerative disorder like Parkinson's, Alzheimer's, or multiple sclerosis.  And certain tumors can impinge on areas that are important for the sense of smell or taste.  

Mattos: They can also be a sign of underlying inflammatory conditions as well, like allergies or hay fever, chronic sinusitis, etc.   

What services are available for people with smell and taste loss? 

Munger: Our approach at UVA Health includes helping patients with strategies to cope with the effects of smell or taste loss. This includes advice about diet, safety, and how to think about the interactions you have with the world around you that are normally mediated by smell and taste.  

Mattos: We take a very thorough course history and do a physical exam. Many times, just by asking key questions we can get to the bottom of the most likely cause.