Dacre Knight, MD

Dacre Knight, MD, is the medical director of the UVA Health Ehlers-Danlos Syndromes & Hypermobility Disorders Center. 

He is board certified in internal medicine and specializes in consultative and diagnostic medicine, with expertise in:

• Ehlers-Danlos syndromes (EDS)
• Hypermobility spectrum disorders
• Chronic multisystem illness
• Complex or unresolved medical conditions

Dr. Knight’s approach to care emphasizes careful diagnostic evaluation, individualized treatment, and coordination across medical specialties. He leads the UVA EDS & Hypermobility Disorders Center with the goal of improving access to comprehensive, multidisciplinary care while helping patients better understand their conditions and make informed decisions about their health.

He is actively involved in research, education, and national efforts to advance the care of people with EDS and related disorders. His research interests include improving the diagnosis and treatment of EDS and hypermobility disorders, characterizing associated multisystem conditions, and developing new diagnostic approaches using artificial intelligence and machine learning. He mentors medical students, residents, fellows, and other trainees and collaborates with investigators across multiple disciplines.

Dr. Knight also serves as chief medical officer of The Ehlers-Danlos Society, where he contributes to clinical education, research strategy, and efforts to improve standards of care for people affected by EDS and hypermobility disorders.

Before joining UVA, Dr. Knight founded and served as medical director of the EDS Clinic at Mayo Clinic in Florida. Earlier in his career, he was an assistant professor of Medicine at Saint Louis University and served for four years as a physician in the United States Air Force at Scott Air Force Base in Illinois. During his military service, he deployed to Afghanistan in support of NATO Operation Resolute Support, cared for combat trauma patients, chaired the hospital infection control committee, and served as medical director of the Clinical Laboratory Education Program.

Dr. Knight earned a master’s degree from George Mason University and his medical degree from St. George’s University. He completed his internal medicine residency at the University of Mississippi Medical Center.

Outside of medicine, he is married and the father of four children. He is also a former NCAA Division III collegiate soccer player.

Organizational Involvement/Memberships

• American College of Physicians, fellow